Gentamicin is an aminoglycoside antibiotic generally used for the treatment of infections and
surgical prophylaxis. Gentamicin is commonly used to treat urinary tract infections, sepsis,
intra-abdominal infections, endocarditis, pelvic inflammatory disease and complicated skin, bone
soft tissue infections. It is not absorbed from the gut when administered orally, and is
predominantly administered via intramuscular or intravenous injection. Gentamicin can cause
dose-related side effects including nephrotoxicity and irreversible hearing loss, so it is
to ensure patients receive the correct dose and are monitored regularly.
Vancomycin is a glycopeptide antibiotic used for treatment of patients with suspected or proven
invasive gram-positive infections, including methicillin-resistant Staphylococcus aureus (MRSA).
Appropriate dosing requires consideration of the infection site, patient weight, renal function,
pathogen susceptibility. Therefore, careful attention to individualizing therapy and prudent use
serum concentration monitoring (when indicated) will assist in selecting the appropriate dose.
undergoes limited absorption when administered orally and is therefore restricted to parenteral
administration for the treatment of systemic infections.
MEG has also been developing Gentamicin and Vancomycin calculators for many Irish hospitals.
Features of MEG devised Gentamicin and Vancomycin calculators:
- Ease of use
- Accurate calculations
- Built based on dosing algorithms provided